Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials, including antibiotics, to improve patient outcomes, reduce microbial resistance, and decrease the spread of infections caused by multidrug-resistant organisms. The goal of antimicrobial stewardship is to optimize the use of antimicrobials to prevent the development of resistance and improve patient outcomes. Antimicrobial stewardship focuses on educating and persuading prescribers of antimicrobials to follow evidence-based prescribing to stem antimicrobial overuse and thus antimicrobial resistance. The effort to measure and improve how antibiotics are prescribed by clinicians and used by patients is critical to effectively treat infections, protect patients from harms caused by unnecessary antibiotic use, and combat antibiotic resistance. Antimicrobial stewardship programs have shown promising results in numerous healthcare settings, including reducing the incidence of C. difficile infection, reducing antimicrobial resistance, improving dosing in renally-impaired patients, improving infection cure rates, decreasing mortality rates, and hospital cost savings. Antimicrobial stewardship is a coordinated effort between interprofessional teams, including clinicians/prescribers, nursing staff, pharmacists, microbiologists, infection prevention teams, and patient safety teams.