what is autosomal dominant

what is autosomal dominant

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Nature

Autosomal dominant is a pattern of inheritance characteristic of some genetic disorders. In this pattern, a single copy of the mutated gene from one parent is enough to cause the disorder. This means that if a parent has an autosomal dominant condition, there is a 50% chance that their child will inherit the condition. Autosomal dominant disorders have pedigrees that demonstrate a vertical pattern of inheritance).

Some key points about autosomal dominant inheritance include:

  • The changed gene is a dominant gene located on one of the non-sex chromosomes, called autosomes.
  • Only one parent needs to have an altered gene to pass it on to their child.
  • Half of the children of a parent with an autosomal trait will get that trait.
  • Autosomal dominant disorders can also occur as a new condition in a child when neither parent has the abnormal gene.

Examples of autosomal dominant disorders include Huntingtons disease, Marfan syndrome, and neurofibromatosis type 1.

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