Batten disease is a rare and fatal disease of the nervous system that typically begins in childhood. It is the most common form of a group of disorders called neuronal ceroid lipofuscinoses (NCLs). Batten disease is an inherited genetic disorder that affects the bodys ability to get rid of cellular waste. The disorder affects the cells’ ability to break down and get rid of cellular waste, which causes problems with the nervous system that eventually leads to death. There are many forms of NCLs, known as CLN1 through CLN14, that are often referred to as Batten disease. The name for each type of Batten disease starts with “CLN” and ends with a number from 1 to 14. The most common type of Batten disease is CLN3 (juvenile Batten disease). Symptoms of Batten disease include seizures, vision loss, cognitive (thinking and reasoning) problems, developmental delays in speech, loss of motor skills, unsteady gait, and eventual death. Treatment options for Batten disease are limited, and there is currently no cure. Physical therapy and occupational therapy may help individuals retain functioning as long as possible. Clinical trials are ongoing to find better ways to safely detect and treat Batten disease.