Brain atrophy refers to the loss of neurons and connections between them in the brains tissues. It can be classified into two main categories: generalized and focal atrophy. Generalized atrophy occurs across the entire brain, whereas focal atrophy affects cells in a specific location. Brain atrophy can be caused by many different disorders, neurodegenerative diseases, infectious diseases, and severe injuries, including stroke, Alzheimers disease, traumatic brain injury, multiple sclerosis, or infections. The symptoms of brain atrophy vary depending on which area of the brain is affected and can range from mild to severe. They can include difficulty speaking, writing, or understanding the meaning of words, memory loss, disorientation, seizures, and loss of coordination, among others. There is no single treatment for brain atrophy, as it can be a sign of one or more diseases. Healthcare providers tailor treatment to help manage the symptoms of the underlying condition, which may include medication, physical and occupational therapy, counseling, speech therapy, or surgery in some cases.