BRCA2 is a human gene that produces a protein that helps repair damaged DNA. The official name of the gene is "breast cancer 2; currently BRCA2, DNA repair associated". BRCA2 is a tumor suppressor gene, found in all humans, and is involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double-strand breaks. If BRCA2 itself is damaged by a BRCA mutation, damaged DNA is not repaired properly, and this increases the risk for breast cancer. BRCA1 and BRCA2 are normally expressed in the cells of breast and other tissue, where they help repair damaged DNA or destroy cells if DNA cannot be repaired. Mutations in the BRCA2 gene are associated with an increased risk of breast cancer in both men and women, as well as several other types of cancer.

Some key points about BRCA2 include:

• BRCA2 is a human gene that produces a protein that helps repair damaged DNA.
• BRCA2 is a tumor suppressor gene, found in all humans, and is involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double-strand breaks.
• If BRCA2 itself is damaged by a BRCA mutation, damaged DNA is not repaired properly, and this increases the risk for breast cancer.
• Mutations in the BRCA2 gene are associated with an increased risk of breast cancer in both men and women, as well as several other types of cancer.