Carprofen is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in dogs. It is specifically indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs. Carprofen works by inhibiting cyclooxygenase (COX) enzymes, thereby inhibiting the release of several prostaglandins involved in chronic inflammatory reactions that are thought to be present in canine osteoarthritis.

Here are some key points to keep in mind about carprofen for dogs:

• Carprofen should not be used in dogs exhibiting previous hypersensitivity to carprofen.
• The safe use of carprofen in animals less than 6 weeks of age, pregnant dogs, dogs used for breeding purposes, or in lactating bitches has not been established.
• Carprofen should be used cautiously in pets younger than 6 weeks of age, older pets, pregnant or lactating pets, dehydrated pets, or pets with pre-existing diseases, especially liver, kidney, heart, or gastrointestinal disease.
• Carprofen should not be used in pets with bleeding disorders such as Von Willebrand disease or those with low platelet counts, or in pets that are allergic to it or other NSAIDs in the same class.
• Carprofen should be used cautiously, if at all in cats, or in pets taking other NSAIDs or corticosteroids.
• Carprofen has high oral bioavailability (90%) and peak plasma concentrations are reached 1 to 3 hours after oral administration.
• Adverse effects of carprofen in dogs may include vomiting, diarrhea, decreased appetite, and lethargy.
• Overall, carprofen is effective in reducing pain in dogs with osteoarthritis.

It is important to follow your veterinarians directions and cautions very carefully when administering carprofen to your dog, as their directions may be significantly different from those on the label.