Cefpodoxime is an antibiotic medication used to treat bacterial infections in dogs. It is a third-generation cephalosporin antibiotic that is effective against certain bacteria causing skin, respiratory, and urinary tract infections. Some of the bacteria that are susceptible to cefpodoxime include Staphylococcus and Pasteurella species, Streptococcus canis, and E. coli. Cefpodoxime is available as tablets and a palatable liquid suspension, which can make treating smaller dogs easier and more accurate. The medication can be given with or without food, and it is recommended to follow the veterinarians directions and cautions very carefully. Cefpodoxime should not be used in pets that are allergic to it or other cephalosporins or penicillins, and it should be used with caution in patients with kidney disease. Cefpodoxime is licensed for dog skin infections caused by certain bacteria, and it is considered off-label for the treatment of urinary tract infections in dogs and for use in cats and horses.