Celebrex (celecoxib) is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain, inflammation, swelling, and stiffness caused by various conditions, including arthritis, ankylosing spondylitis, migraines, menstrual pain, and acute pain. It is a COX-2 inhibitor, which means it works by blocking the enzyme in the body that makes prostaglandins, thereby reducing pain and swelling. Celebrex is taken once or twice a day, and the usual dose is 200 to 400 mg per day. It is available in capsule form and should be taken with or without food. Celecoxib is less likely to cause stomach upset and ulcers than other NSAIDs, but it may still cause stomach problems in some cases. Celebrex should not be taken by people who have a known allergy to sulfa drugs. It is important to talk to a doctor about the risks and benefits of taking Celebrex, as it may increase the risk of heart attack or stroke, especially if taken for a long time.