Cor pulmonale is a condition that causes the right side of the heart to fail due to long-term high blood pressure in the arteries of the lung and right ventricle. It is defined as an alteration in the structure and function of the right ventricle of the heart caused by a primary disorder of the respiratory system resulting in pulmonary hypertension. The right ventricle of the heart becomes enlarged and weakened, leading to symptoms such as shortness of breath, bulging veins in the neck, swelling in the legs or belly, fatigue, chest pain, and fainting episodes. Cor pulmonale is caused by lung conditions that cause pulmonary hypertension, such as chronic obstructive pulmonary disease (COPD), pulmonary embolism, or trauma or surgery that removes lung tissue. Treatment of cor pulmonale focuses on improving the lung issue that caused it, such as treating the underlying condition, improving oxygenation, and helping the right ventricle work better. The diagnosis and management of cor pulmonale are by an interprofessional team that consists of a cardiologist, internist, radiologist, pulmonologist, and intensivist.