CRE stands for carbapenem-resistant Enterobacterales, which is a group of bacteria that are resistant to carbapenem antibiotics, which are considered the last line of defense to treat multidrug-resistant bacterial infections. Enterobacterales are a large order of different types of germs (bacteria) that commonly cause infections in healthcare settings. CRE are difficult to treat because they do not respond to commonly used antibiotics, and occasionally, they are resistant to all available antibiotics. CRE are a major concern for patients in healthcare settings because they are resistant to carbapenem antibiotics, which are considered the last line of defense to treat multidrug-resistant bacterial infections. CRE infections are most common in patients in hospitals and long-term care facilities like skilled nursing facilities and long-term acute care hospitals. CRE are usually spread person to person through contact with infected or colonized people, particularly contact with wounds or stool (poop) . Symptoms of CRE-related infections include fever and a rapid pulse, and other symptoms depend on which type of infection a person has. If CRE are resistant to most available antibiotics, a doctor will work out the best treatment plan for the individual, which may include using medicines to reduce fever, trying nutritional therapy, closely monitoring heart rate and other vital signs, taking intravenous fluids, and treating any other health conditions present.