Creon is a prescription medication used to treat exocrine pancreatic insufficiency (EPI), a condition where the pancreas does not make enough enzymes to digest food normally. Creon is a pancreatic enzyme replacement therapy (PERT) that contains three enzymes (proteins): lipase, protease, and amylase, which are normally produced by the pancreas and are important in the digestion of fats, proteins, and sugars. Creon capsules are taken with meals and snacks so they can enter the stomach at the same time as food. The capsules release tiny, coated spheres containing pancreatic enzymes that dissolve at the starting point of the small intestine, called the duodenum. In the small intestine, the enzymes work to break down fats, proteins, and carbohydrates (sugars) in food. Creon is used to treat EPI caused by cystic fibrosis, chronic pancreatitis, pancreatectomy, or other conditions. Creon does not cure EPI, but it can help replace the digestive enzymes that the pancreas no longer makes.