Desonide cream is a corticosteroid medication used to treat various skin conditions that cause redness, swelling, itching, and discomfort, such as eczema, dermatitis, allergies, and rash. It works by activating natural substances in the skin to reduce swelling, redness, and itching. Desonide cream comes in different forms, including cream, ointment, gel, foam, and lotion, and is applied to the affected area of the skin with a thin even film and rubbed in gently. It is usually applied two to four times a day, and the directions on the prescription label should be followed carefully. Desonide cream should only be used on the skin and should not be applied to the eyes, nose, mouth, genital and rectal areas, and skin creases and armpits unless directed by a doctor. It is important to avoid using desonide cream on healthy skin or over large areas of skin, and to wash hands before and after use. If a favorable response does not occur promptly, use of desonide cream should be discontinued until the infection has been treated.