The double marker test, also known as maternal serum screening, is a predictive test that detects chromosomal abnormalities in the fetus of a pregnant woman. It is a prenatal screening test that involves measuring the quantity of two markers, beta-human chorionic gonadotropin (êžµ-hCG, a pregnancy-related hormone), and pregnancy-associated plasma protein A (PAPP-A) in the blood erythrocytes. The test is typically performed during the first trimester of pregnancy, between weeks 11 and 14. The double marker test helps determine whether the unborn baby has any risk of developing neurological abnormalities or mental disorders, such as Down syndrome or Trisomy 21, Trisomy 18, and Trisomy 13, which cause mental and physical challenges in the baby. The test is not a definitive test but a predictive test, which means its results report the likelihood of chromosomal abnormalities. The test results are typically presented in the form of ratios, which can be used to estimate the likelihood of a child having any given condition. If the test results suggest an increased risk of chromosomal abnormalities, the mother may be offered further diagnostic tests, such as an amniocentesis, to confirm the results. The cost of the double marker test varies depending on the reputation of the institution, the accuracy of the test results, and the requirements of the machines, but it ranges somewhat between Rs 2,500 to Rs 4,000 on average. Before deciding whether to have a double marker test, its important to consider what the outcomes may imply for you down the road, and its all about personal choice and your own health history[[1]](https://w...