Fenofibrate is a medication used to treat high cholesterol and triglyceride levels in the blood. It works by decreasing bad cholesterol and fats (such as LDL, triglycerides) and increasing good cholesterol (HDL) in the blood. Fenofibrate belongs to a group of medications called fibrates. It is usually taken once a day with a low-fat diet, exercise, and sometimes with other medications. Fenofibrate may be used for other purposes as well, but it is important to ask a healthcare provider or pharmacist if there are any questions.