what is gmg disease

what is gmg disease

1 year ago 59
Nature

GMG disease is not a known medical condition. However, there is a neuromuscular disease called myasthenia gravis (MG), which is a chronic autoimmune disorder that causes weakness in the skeletal muscles. It is caused by abnormal antibodies that attack the neuromuscular junction (NMJ), where nerves and muscles meet, and damage it. The symptoms of MG include drooping of one or both eyelids, slurred speech, choking, impaired swallowing, double or blurred vision, disabling fatigue, immobility requiring assistance, shortness of breath, and episodes of respiratory failure. The disease can occur at any age but most commonly begins for people under 40 and over 60. There are different types of MG, including seronegative myasthenia gravis, which is a type of myasthenia gravis that isnt caused by antibodies blocking acetylcholine, MuSK or LRP4. While most MG symptoms can be managed with existing MG therapies, 10% to 15% of patients fail to respond adequately to or cannot tolerate multiple therapies for MG and continue to suffer profound muscle weakness and severe disease symptoms that limit function.

Read Entire Article