HPB stands for Hepato-Pancreato-Biliary, which refers to medical conditions and procedures related to the liver, pancreas, gallbladder, and bile ducts. HPB surgery is a type of surgery that treats benign and malignant diseases of these organs. The International Hepato-Pancreato-Biliary Association (IHPBA) is a non-profit organization established in 1994 that focuses on medical conditions and procedures related to the liver, pancreas, and biliary tract. The organization established the journal HPB in 1999 and has held world congresses since 1994.

Johns Hopkins Medicine offers minimally invasive HPB surgery options and has one of the highest surgical volumes for hepato-pancreato-biliary surgery. Other medical centers, such as the University Centers of Excellence and TriHealth, also offer HPB surgery programs.

HPB surgery can treat a variety of conditions, including primary liver cancer, liver tumor removal, pancreatic tumors, gallbladder and bile duct tumors, and pancreatic cystic neoplasms. After undergoing HPB surgery, patients may need to follow a specific diet and pain control plan.