A hypodense lesion in the liver is a type of liver lesion that appears darker than the surrounding liver tissue on a non-contrast CT scan. It can result from a number of pathological entities, including neoplasms, benign or malignant, such as hepatic hemangioma, adenoma, focal nodular hyperplasia, and hepatocellular carcinoma. A hypodense lesion in the liver can also be caused by cysts, hepatic hydatid infection, or biliary tree dilatation. If a hypodense lesion is detected, further diagnostic workup is necessary to determine the nature of the lesion, which may include imaging tests such as MRI, CT, or PET scans, and biopsy. The treatment of hypodense lesions in the liver depends on the nature of the lesion, whether it is cancerous or not.