Multiple system atrophy (MSA) is a rare, degenerative neurological disorder that affects the bodys involuntary (autonomic) functions, including blood pressure and motor control. It is characterized by a combination of symptoms that affect both the central nervous system and the autonomic nervous system. MSA was formerly known as Shy-Drager syndrome, olivopontocerebellar atrophy, or striatonigral degeneration. The symptoms of MSA are wide-ranging and include muscle control problems, similar to those of Parkinsons disease, as well as bladder control problems, fainting or lightheadedness, and clumsiness or lack of coordination. One distinguishing feature of MSA is the buildup of a protein called alpha-synuclein in glia, specialized cells that support nerve cells in the brain. There is no known cure for MSA, but treatment includes medications and lifestyle changes to help manage symptoms. The condition progresses gradually and eventually leads to death.