Neomycin and polymyxin b sulfates and bacitracin zinc ophthalmic ointment is an antibiotic medication used to treat eye and eyelid infections caused by bacteria. The combination of neomycin, polymyxin, and bacitracin works by stopping the growth of bacteria infecting the surface of the eye. This medication is for use in the eye only and should be applied inside the lower lid of the infected eye every 3 to 4 hours for 7 to 10 days, as directed by a doctor. It is important to follow the directions on the prescription label carefully and not use more or less of it or use it more often than prescribed by a doctor. If the symptoms do not go away or get worse, it is important to call a doctor. This medication should not be shared with anyone else, even if they were also prescribed this medication, as infection may spread.