The NFLs Crucial Catch is a campaign that aims to fight cancer through early detection and risk reduction. The campaign is a partnership between the NFL, its clubs, players, the NFL Players Association, and the American Cancer Society. The campaign promotes cancer prevention and early detection by providing individuals with the tools they need to better understand early detection and ways to reduce their cancer risk.

Every year, every NFL team raises awareness during their Crucial Catch game, which features on-field and in-stadium Crucial Catch elements. Crucial Catch games also present a special opportunity to honor cancer survivors and those currently battling cancer. The campaign also empowers fans to take their health into their own hands by getting screened for cancer and educating themselves on the importance of cancer screening.

The campaign also includes community grants and partnerships with companies such as Sleep Number to broaden its impact. In Canada, the NFL Crucial Catch games raise awareness for cancer prevention with players, coaches, fans, and referees in apparel supporting multiple types of cancer. Tie-dye designs were introduced to promote the Crucial Catch Program initiated by the ACS as the program helps with the detection and early treatment of cancer.