Non-bio detergent is a type of laundry detergent that does not contain enzymes, unlike bio detergent. Enzymes in bio detergents help break down tough stains, but they can also damage certain fabrics and irritate sensitive skin. Non-bio detergents are gentler on sensitive skin and are popular with families who have sensitive skin or allergies. They still contain powerful cleaning agents that ensure clothing comes out of the washing machine clean and fresh, but may require a slightly higher temperature to tackle tough stains. Non-bio detergents are also preferable when washing delicate fabrics such as silk and wool, which can be damaged by the enzymes in bio detergents. Both bio and non-bio detergents can be added directly to the washing machine, and there is no difference in how they are used.