Pandora Syndrome is a term used to describe a condition in cats that results from chronic anxiety and stressors that the cat finds threatening. The syndrome is characterized by variable combinations of chronic lower urinary tract signs, such as hematuria, pollakiuria, periuria, and stranguria, as well as comorbid health problems. Cats with Pandora Syndrome are typically anxious and have a history of chronic concurrent illnesses in various body systems. They may also have an exaggerated pain response and be in a constant state of "fight or flight".

The diagnosis of Pandora Syndrome is often confirmed by decreased frequency, severity, and duration of symptomatic flare-ups in response to implementation of Multimodal Environmental Modification (MEMO) . MEMO involves treatment via enhancement of the cats environment to create a stable, predictable home life.

A tentative diagnosis of Pandora Syndrome rests primarily on the results of a comprehensive history and physical examination. Decisions about medical care of cats with Pandora Syndrome depend on the specific presenting problem(s) . A diagnosis of Pandora Syndrome means that an anxiopathy has been identified and, to the extent possible, other causes of the signs have been excluded.

In summary, Pandora Syndrome is a condition in cats that results from chronic anxiety and stressors. It is characterized by chronic lower urinary tract signs and comorbid health problems. The diagnosis is confirmed by decreased frequency, severity, and duration of symptomatic flare-ups in response to implementation of Multimodal Environmental Modification (MEMO).