Panthenol is a chemical substance made from pantothenic acid, also known as vitamin B-5, and is used as an additive in various cosmetic products around the globe. It is a stable, water-soluble, light ingredient that readily penetrates the skin. Panthenol is used in skincare and cosmetic products due to its moisturizing, soothing, and anti-inflammatory properties. It is also included in many cosmetics as a softening, soothing, and anti-irritant agent. Panthenol helps improve skin’s hydration, elasticity, and smooth appearance, and soothes red skin, inflammation, little cuts or sores like bug bites or shaving irritation. It also helps with wound healing, as well as other skin irritations like eczema. Panthenol is non-comedogenic, meaning it is a safe moisturizing ingredient for acne-prone skin types and is not likely to contribute to the development of comedones. Panthenol is a humectant, which means it is a moisturizing agent that draws water into the outer layer of the skin (stratum corneum), from deeper levels and from the air. By hydrating this layer of skin, panthenol exerts a revitalizing effect which leads to smoother, softer skin. Using daily formulations of panthenol maintains the skin barrier, which leads to a reduction of transepidermal water loss (water being lost from the outermost layer of the skin) . Panthenol is generally considered safe for use in skincare products.