Peripheral artery disease (PAD) is a condition where the arteries that carry blood from the heart to the legs or arms become narrowed or blocked due to the buildup of fatty deposits in the arteries, a process called atherosclerosis. This can cause reduced blood flow to the limbs, leading to symptoms such as leg pain when walking (claudication) and numbness. PAD is similar to coronary artery disease (CAD), which is caused by atherosclerosis in the arteries that supply blood to the heart. Risk factors for PAD include smoking, high blood pressure, high cholesterol, diabetes, and age above 60 years. Diagnosis of PAD involves a physical exam and heart and imaging tests. Treatment includes lifestyle changes, such as exercising, eating a healthy diet, and not smoking, as well as medications and sometimes surgery. If you have leg pain, numbness, or other symptoms of PAD, it is important to call your healthcare provider.