RLS stands for Restless Legs Syndrome, which is a neurological disorder that causes an uncontrollable urge to move the legs, usually because of an uncomfortable sensation. The sensations associated with RLS are distinct from normal sensations experienced by those who don’t have the disorder, and they typically occur when you lie down or sit for a prolonged time. Common accompanying characteristics of RLS include sensations that begin while resting, relief with movement, and difficulty falling or staying asleep. The cause of RLS is still unknown, but it often runs in families, and specific gene variants have been associated with the condition. Low levels of iron in the brain may also be responsible for RLS. RLS is generally a lifelong condition for which there is no cure, but treatments are available to ease symptoms. Treatment options for RLS may include following good sleep habits, stopping activities that worsen symptoms, giving up caffeine, alcohol, and tobacco, regular moderate exercise, and iron therapy.