Sepsis is a potentially life-threatening condition that occurs when the body's response to an infection causes injury to its own tissues and organs. It is essentially the body's extreme and toxic response to an infection, leading to widespread inflammation and damage. The infection can be caused by bacteria, viruses, fungi, or parasites, and commonly starts in the lungs, urinary tract, skin, gastrointestinal tract, or other parts of the body. When the body tries to fight the infection, the immune system releases chemicals that can trigger a chain reaction, causing the immune system to harm the body's own organs and tissues. This can lead to organ dysfunction and failure, and if untreated, can progress to septic shock, which includes severely low blood pressure and can be fatal. Symptoms of sepsis may include fever, increased heart rate, rapid breathing, confusion, extreme pain or discomfort, clammy or sweaty skin, and other signs indicating organ distress. Sepsis is a medical emergency requiring prompt recognition and treatment to prevent serious outcomes, including death. High-risk groups include the very young, the elderly, individuals with weakened immune systems, chronic illnesses, or recent surgeries or infections. In summary, sepsis is an overwhelming and damaging immune response to an infection that causes tissue and organ damage, and rapid intervention is critical to improve outcomes. This overview is supported by information from multiple reputable medical sources and organizations.