Sucralfate is a medication used to treat and prevent duodenal ulcers and other conditions as determined by a doctor. It works by forming a protective layer over the ulcer, which protects it from stomach acid and allows it to heal. Sucralfate is in a class of medications called protectants. It is also used to treat epithelial wounds, chemotherapy-induced mucositis, radiation proctitis, ulcers in Behcet disease, and burn wounds. Sucralfate exhibits its action by forming a protective layer, increasing bicarbonate production, exhibiting anti-peptic effects, promoting tissue growth, regeneration, and repair. It has a relatively safe profile as there is negligible absorption from the enteral system.

Sucralfate comes as a tablet and liquid to take by mouth. If taking sucralfate to treat ulcers, the tablets or liquid are usually taken four times a day. If taking sucralfate to prevent an ulcer from returning after it has healed, the tablets are usually taken twice a day. It should be taken on an empty stomach, 2 hours after or 1 hour before meals, and around the same times every day. The dosage is based on the medical condition and response to treatment. It may take up to 8 weeks for ulcers to heal.

Sucralfate has also been used to treat various off-label (non-FDA approved) conditions such as dyspepsia, which is shown to reduce the frequency and intensity of dyspeptic symptoms and gastric erosion during NSAID therapy, and the efficacy is similar to that of an H-2 receptor blocker. It is also used topically in the treatment of skin conditions and mucosal ulcers.

It is important to follow the directions on the prescription label carefully and take sucralfate exactly as directed. Do not take more or less of it or take it more often than prescribed by a doctor. If experiencing side effects or if the condition lasts or gets worse after taking sucralfate for 4 weeks, inform a doctor.