The best antibiotic for an ear infection depends on several factors, including the type of infection, the age of the patient, and the severity of the symptoms. Most ear infections are caused by viruses and can clear up on their own with rest, self-care, and over-the-counter pain relievers. However, antibiotics are necessary if bacteria are causing the ear infection. Amoxicillin is usually the first choice of doctors because it is effective against most common bacterial infections and is well-tolerated by most people. Other antibiotics that may be prescribed for ear infections include amoxicillin/clavulanate (Augmentin), azithromycin (Zithromax), erythromycin, trimethoprim/sulfamethoxazole (Bactrim), and doxycycline (Doryx) . It is important to follow the directions for whichever antibiotic your healthcare provider prescribes and to complete the entire treatment to avoid recurrent infections and antibiotic resistance.