The best antibiotic for a gum infection is often amoxicillin, which is commonly prescribed because it effectively targets many bacteria that cause gum infections. Another frequently used antibiotic is metronidazole, which is particularly effective against anaerobic bacteria found in deep gum pockets. Sometimes, a combination of amoxicillin and metronidazole is used to cover a broader range of bacteria. Other antibiotics used for gum infections, especially for more stubborn or advanced cases, include clindamycin, doxycycline, and azithromycin. Topical antibiotics such as minocycline microspheres (Arestin®), doxycycline gel (Atridox®), and chlorhexidine chips (PerioChip®) can also be applied locally to infected areas in the gums for targeted treatment. Antibiotics should always be taken as prescribed by a dentist or healthcare provider to ensure effectiveness and minimize risks like antibiotic resistance or side effects. Mild cases of gum infection may also be managed with proper dental cleaning and oral hygiene without antibiotics. Overall, amoxicillin and metronidazole remain the primary choices for treating gum infections.