The best decongestant depends on your specific needs, but here are some top options based on effectiveness, form, and use case:

• Sudafed (pseudoephedrine) is widely regarded as the most effective oral decongestant for relieving nasal congestion caused by colds, flu, or allergies. It works by narrowing blood vessels in the nasal passages to reduce swelling and improve airflow. Sudafed provides relief for up to 12 hours but is available behind the pharmacy counter due to regulations and is not recommended for people with high blood pressure or certain conditions

• Afrin No Drip (oxymetazoline nasal spray) is the best nasal spray for fast relief of severe congestion. It acts directly on nasal tissues to quickly reduce inflammation and open nasal passages. However, it should only be used short-term (no more than 3 days) to avoid rebound congestion

• Allegra Allergy (fexofenadine) is a good nondrowsy oral antihistamine option for congestion caused by allergies. It is taken once daily and also relieves sneezing and runny nose but is not for children or those with kidney issues

• Flonase Allergy Relief (fluticasone nasal spray) is effective for congestion due to allergies, including pet allergies. It is a corticosteroid that reduces inflammation in nasal passages and can be used regularly but not for acute infections

• For children, Little Remedies Decongestant Nose Drops offer a gentle option without drowsiness

• For nighttime relief with drowsiness, Mucinex Nightshift combines a decongestant with an antihistamine to help with sleep

In summary, for general and strong decongestant effect, Sudafed (pseudoephedrine) is considered the best oral option, while Afrin nasal spray is best for rapid nasal relief. Allergy-related congestion may be better treated with antihistamines like Allegra or corticosteroid sprays like Flonase