Cyberpunk 2077 has multiple endings, and the best ending is subjective and depends on the players preferences. However, according to Game Rant, the best ending in Cyberpunk 2077 is the "Panam" ending. In this ending, V and Panam leave Night City and start a new life together. Vs health is deteriorating, but they have Panam by their side, and they can face their mortality together. This ending is considered the best because it is the most fulfilling and emotional, and it provides a sense of closure to Vs story.

However, other sources have different opinions on the best ending. For example, the secret ending is considered by some to be the best. This ending is challenging to obtain, but it saves the most lives and has V undertake the final mission alone with Johnny. The "Nomad" ending with female V who romanced Judy is also a popular choice.

Ultimately, the best ending in Cyberpunk 2077 is a matter of personal preference, and players should choose the ending that resonates with them the most.