The best seed in general gardening depends on the context: whether it's a real-life vegetable garden or the game "Grow a Garden." For real-life vegetable gardening, some of the best seeds to plant for a successful garden include lettuce, brassicas (like broccoli and cabbage), spring radishes, chard, beets, legumes, basil, summer squash, and cucumbers. Lettuce is particularly good for spring planting, as it grows fast and is tolerant of cool weather, making it great for beginners and quick harvests.

For the game "Grow a Garden," the best seeds based on tier lists for value and harvest efficiency are:

• S+ Tier (top seeds): Maple Resin, Bone Blossom, Candy Blossom
• S Tier: Maple Apple, Golden Peach, Wispwing, Princess Thorn, Gleamroot, Spirit Flower, Kniphofia, Amberheart, Sunflower, Dragon Pepper, and more
  These top-tier seeds provide great value, repeated harvests, and high selling prices in the game.

If the question is about a common gardening practice in real life, lettuce and easy-to-grow vegetables and herbs are often recommended as the best starting seeds for a garden. If the question is about the game "Grow a Garden," then top-tier seeds like Maple Resin and Candy Blossom are the best to plant for profit and continual harvest. Please clarify if the focus is on real gardening or the "Grow a Garden" game for a more precise recommendation.