Squamous cell carcinoma is a type of skin cancer that can be cured when found and treated early. The best treatment for squamous cell carcinoma depends on the size and location of the growth, as well as the patients overall health. Here are some of the most common treatment options:

1. Surgery: Surgical removal is often recommended to remove squamous cell lesions, particularly those classified as high risk. Different types of surgery can be used to treat squamous cell skin cancers, including excision, Mohs surgery, and laser surgery.

2. Radiation therapy: Radiation therapy is often a good option for patients with large cancers, especially in areas where surgery would be hard to perform. There are different types of radiation therapy, including superficial radiation therapy, external beam radiation therapy, and brachytherapy.

3. Topical medications: Two topical medications, 5-fluorouracil (5-FU) and imiquimod, can be applied directly onto the affected skin as treatment for superficial squamous cell carcinomas. Imiquimod stimulates the immune system to fight back against cancerous cells, while 5-FU kills tumor cells on or near the skins surface.

4. Immunotherapy: For advanced squamous cell cancers that cant be cured with surgery or radiation therapy, one option might be using an immunotherapy drug such as cemiplimab (Libtayo) or pembrolizumab (Keytruda) .

5. Chemotherapy: Chemotherapy drugs may be an option if the squamous cell skin cancer is spreading. Given intravenously once every few weeks, chemotherapy may slow the spread of the cancer and/or help relieve some symptoms.

Mohs surgery is considered the most effective technique for removing SCCs, sparing the greatest amount of healthy tissue while achieving the highest possible cure rate. However, the choice of treatment depends on the tumor type, size, location, and depth, as well as the patients age and overall health.