The phrase "What's the Difference" primarily refers to a song by Dr. Dre featuring Eminem and Xzibit from Dr. Dre's 1999 album 2001. The song explores differences between the rappers themselves and others in the hip hop industry, with Dr. Dre reflecting on friends like Ice Cube, The D.O.C., and Eazy-E, while Eminem delivers a vivid, intense verse defending Dre's legacy and contemplating dark themes

. If you are asking about the general meaning of "difference," it is defined as the way in which two or more things are not the same, or the amount by which one thing differs from another. It can refer to distinctions in quality, characteristics, or opinions between items or people

. To summarize:

• "What's the Difference" (song) : A hip hop track by Dr. Dre featuring Eminem and Xzibit, discussing personal and artistic differences in the rap world

• General meaning of difference : The characteristic or amount by which two or more things differ from each other

If you meant to ask about the difference between two specific things, please clarify what those are for a more precise comparison.