The most addictive drugs are those that act on the pleasure center in the brain, causing a shortcut to reward that, when repeated, can change the way a person processes information. The addictive qualities of drugs may be enhanced by how good they make a person feel when using them and how bad they may make users feel when they wear off. The most addictive drugs vary depending on the source, but here are some of the most commonly cited ones:

• Heroin: Heroin is an opiate that causes the level of dopamine in the brain’s reward system to increase by up to 200% in experimental animals. It is considered to be the most addictive drug by many researchers.

• Fentanyl: Fentanyl is a synthetic opioid that is 50-100 times more potent than morphine. It is highly addictive and can lead to physical dependence and withdrawal symptoms if use is stopped abruptly.

• Opioid painkillers: Opioid painkillers, such as prescription painkillers like OxyContin and fentanyl and illegal drugs like heroin, are highly addictive and can lead to physical dependence and withdrawal symptoms if use is stopped abruptly.

• Cocaine: Cocaine is an addictive stimulant that is derived from the coca plant. It is commonly mixed with other substances such as starches, flours, or even other drugs like amphetamines and opioids. Cocaine is typically taken by snorting and quickly delivers dopamine to the brain, creating an intense high that is short-lived.

• Alcohol: Alcohol is the most widely used psychoactive drug in America. It is highly addictive and can lead to physical dependence and withdrawal symptoms if use is stopped abruptly.

It is worth noting that not all individuals who use these most addictive drugs will become addicted, but regular use of these drugs can lead to addiction. It is also important to consult with a doctor or a healthcare professional before using any kind of drug, to have a better understanding of the risks and benefits associated with it.