Arthritis is a condition that causes pain and stiffness in the joints, and there are several medications available to manage arthritis pain. The most effective medication for arthritis depends on the type of arthritis and the individuals specific symptoms. Here are some of the most commonly used medications for arthritis pain relief:

• Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): NSAIDs are the most effective oral medicines for osteoarthritis (OA) and are used for both inflammatory arthritis and OA. They include ibuprofen (Motrin, Advil), naproxen (Aleve), and diclofenac (Voltaren, others). All work by blocking enzymes that cause pain and swelling.

• Topical NSAIDs: Before trying pills, experts recommend trying topical NSAIDs for OA pain. These come in prescription liquids (Pennsaid) and patches (Flector). Gel (Voltaren) is now available over-the-counter without a prescription. Studies show they can relieve knee pain just as well as pills, but with fewer side effects.

• Acetaminophen: Acetaminophen (Tylenol) is available over-the-counter and is often used for arthritis because it doesn’t hurt your heart and stomach the way NSAIDs can. However, recent studies suggest that acetaminophen does little for OA pain. The American College of Rheumatology (ACR) and Arthritis Foundation (AF) treatment guidelines released in 2020 don’t recommend it unless you can’t use NSAIDs. But it may help OA pain for some people. Acetaminophen can harm your liver, so never take more than prescribed and only use it as needed.

• Corticosteroids: Corticosteroids, sometimes called steroids or glucocorticoids, reduce inflammation by acting like your natural hormone cortisol. They work quickly so are good for flare-ups. They can be taken orally or injected into the joint.

• Biologics: Biologics are a newer class of drugs that target specific parts of the immune system that cause inflammation. They are used to treat inflammatory types of arthritis, such as rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). Different biologics target different interleukins (IL-1, IL-6, IL-17, IL-12, and IL-23) to disrupt the inflammatory process at the root of inflammatory arthritis.

• Counterirritants: Some varieties of creams and ointments contain menthol or capsaicin, which create a sensation of heat or cold that can distract from the pain.

It is important to note that medication is not the only way to manage arthritis pain. Non-drug options, such as exercise, weight loss, physical therapy, and joint protection, can also be effective in managing arthritis pain[[4]](https://www.mayoclinic.org/diseases-conditions/...