There is no specific normal or abnormal level of PSA in the blood. In the past, PSA levels of 4.0 ng/mL and lower were considered normal. However, some individuals with PSA levels below 4.0 ng/mL have prostate cancer, and many with higher PSA levels between 4 and 10 ng/mL do not have prostate cancer. The normal range of PSA levels varies from man to man, and the level increases as men get older. The following are some general guidelines for interpreting PSA levels based on age:

• For men in their 40s and 50s: A PSA score greater than 2.5 ng/mL is considered abnormal. The median PSA for this age range is 0.6 to 0.7 ng/mL.
• For men in their 60s: A PSA score greater than 4.0 ng/mL is considered abnormal. The normal range is between 1.0 and 1.5 ng/mL.

Its important to remember that a PSA level higher than 3ng/mL may be normal in older men. Doctors will consider many factors before suggesting when to start prostate cancer screening, and the decision to have a PSA test should be made after considering the uncertainties surrounding PSA testing, as well as the potential risks and benefits.