The prefrontal cortex (PFC) is a part of the brain located at the front of the frontal lobe, and it is involved in many functions. The PFC is highly interconnected with much of the brain, including extensive connections with other cortical, subcortical, and brain stem sites. The PFC is responsible for executive functions, such as planning, decision making, working memory, personality expression, moderating social behavior, and attention. It helps people set and achieve goals, process information, and adapt accordingly. The PFC contributes to a wide variety of executive functions, including focusing one’s attention, predicting the consequences of one’s actions, anticipating events in the environment, impulse control, and managing emotional reactions. The PFC also creates a “mental sketch pad” through networks of neurons that can maintain information in the absence of environmental stimulation. The PFC intelligently regulates our thoughts, actions, and emotions through extensive connections with other brain regions. The PFC is divided into subregions, including the dorsal lateral, dorsal medial, ventral lateral, ventral medial, and orbital frontal regions.