The Baltimore Orioles lost the game against the Houston Astros on August 17, 2025, with a final score of 5-4 in favor of the Astros. The game went into extra innings, with the Astros scoring the winning run in the 12th inning. Summary of key scoring moments:

• Orioles scored 2 runs in the 5th inning.
• Astros scored 3 runs by the 4th inning, then added more runs later.
• Astros won with a 5th run in the 12th inning.

So, the final score was Houston Astros 5, Baltimore Orioles 4 on August 17, 2025. The Astros won the series as well.