Trimethylglycine (TMG), also known as betaine or betaine anhydrous, is a substance that can be produced by the body and is found in certain foods and supplements. It is an amino acid derivative that was first discovered in sugar beets in the 19th century. TMG functions as a methyl donor, which means it helps to convert potentially harmful homocysteine into the antioxidant methionine. TMG is involved in the process called methylation, which is crucial for DNA production and the proper functioning of the cardiovascular, nervous, and endocrine systems.

TMG has several potential health benefits, including improved mood, energy, and heart health. It may also help to neutralize homocysteine, which can build up in the blood and raise the risk of heart disease. Additionally, TMG supplements could improve how well certain types of antidepressant medications work. TMG has been FDA-approved as a treatment for rare genetic conditions where the body cannot dispose of homocysteine, resulting in its accumulation to extremely high levels, leading to accelerated cardiovascular disease and other problems.

TMG is found in many foods, including wheat bran, wheat germ, quinoa, spinach, and beets. However, most TMG in food is destroyed during cooking or processing, so food isnt a reliable way to get a therapeutic dosage. Optimal therapeutic dosages of TMG are not known, but common recommendations range from 375 to 3,000 mg daily. It is important to consult a healthcare professional before taking TMG supplements, especially if you have any underlying medical conditions or are taking medications.