Topiramate is a medication used to treat certain types of seizures, including primary generalized tonic-clonic seizures and partial onset seizures, either alone or with other medications. It is also used to control seizures in people who have Lennox-Gastaut syndrome, a disorder that causes seizures and developmental delays. Additionally, topiramate is used to prevent migraine headaches but not to relieve the pain of migraine headaches when they occur in adults and children 12 years of age and older. Topiramate is in a class of medications called anticonvulsants, and it works by decreasing abnormal excitement in the brain.

Topiramate is also sometimes used for the management of alcohol dependence and for the treatment of binge eating disorder and essential tremors (a movement disorder that causes involuntary shaking, especially in the hands) . However, it is important to talk to a doctor about the risks of using this medication for these conditions. There are many off-label uses for topiramate, including neuropathic pain, psychotropic drug-induced weight gain, alcohol use disorders with tobacco dependence, cluster headache prevention, bulimia nervosa, obesity with hypertension, prevention of neuralgiform attacks, adjunctive therapy in bipolar disorder, unipolar depression, borderline personality disorder, obsessive-compulsive disorder, posttraumatic stress disorder, Tourette syndrome, Prader-Willie syndrome, essential tremor, and more.