Trimix injection is a medication used to treat erectile dysfunction (ED) . It is a compounded drug that consists of three medications: papaverine, phentolamine, and alprostadil. Trimix is injected directly into the side of the penis, and it works by enhancing blood flow to the penile tissues, resulting in longer and firmer erections that last through climax. Trimix injections can trigger an erection within 5 minutes. The dosage of Trimix is customized to each patients needs and must be prescribed by a healthcare provider. The injection process may cause minimal discomfort for some individuals, but it is generally well-tolerated, thanks to fine-gauge needles and careful administration techniques. Trimix injections are typically self-administered at home after receiving a physicians instructions. The optimal locations to administer the Trimix injection are at the sides of the penis, and the same spot should not be used repeatedly for injections. Some men experience pain or bruising, while others experience none at all. Other side effects include temporary swelling of the penis skin. Priapism, an erection that lasts longer than four hours, is a rare but serious side effect of Trimix injection.