Deion Sanders has suffered serious complications in his left foot due to blood clots and poor circulation. In 2021, he had two toes amputated on his left foot after developing life-threatening blood clots during a prolonged hospital stay. He also experienced a dislocated toe, an inflamed nerve, and compartment syndrome, which required multiple surgeries including opening his leg to drain fluid

. Despite the amputations, Sanders continues to face ongoing blood flow problems in that foot. Doctors have warned that if the circulation issues are not addressed, he risks losing his entire left foot. He has no feeling in the bottom of his foot and has had multiple arteries close after previous procedures, leaving only one artery supplying blood to the foot

. Sanders has undergone at least 11 surgeries to treat these blood clotting issues and recently had surgery to straighten two remaining toes that cause him pain. He remains determined to recover and return to coaching and running, despite the severity of his condition

. In summary, Deion Sanders' foot problems stem from blood clots that led to the amputation of two toes and ongoing poor circulation, putting him at risk of further amputations including potentially his entire left foot