xTrain is an online application that is part of the eRA Commons system of the National Institutes of Health (NIH) . It allows program directors/principal investigators, university administrators, and trainees to electronically prepare, submit, and track the PHS 2271 Statement of Appointment forms and PHS 416-7 Termination Notices associated with institutional research training grants, institutional career development awards, individual fellowships, and research education awards. xTrain is also used by Agency grants management staff to review and process the Appointments and Termination Notices submitted electronically.

In summary, xTrain is an electronic system used by NIH to manage the appointment and termination of trainees associated with institutional research training grants, institutional career development awards, individual fellowships, and research education awards.