Zofran (ondansetron) is primarily used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. It works by blocking serotonin 5-HT3 receptors in the gut and brain, which are involved in triggering nausea and vomiting

. Additional uses include:

• Prevention of postoperative nausea and vomiting
• Relief of nausea and vomiting related to migraines and morning sickness (off-label use)
• Treatment of vomiting episodes in gastroenteritis and cyclic vomiting syndrome
• Management of diarrhea-predominant irritable bowel syndrome (IBS-D) symptoms

Zofran is available in various forms including oral tablets, orally disintegrating tablets, oral solution, and injectable forms

. In summary, Zofran is mainly prescribed to prevent and treat nausea and vomiting associated with cancer treatments, surgery, and other medical conditions involving these symptoms