Zoster immunization is a vaccination that helps prevent shingles and postherpetic neuralgia (PHN), which is the most common complication from shingles. Shingles is a painful rash that usually develops on one side of the body, often the face or torso, and is caused by the reactivation of the same virus that causes chickenpox. Zoster immunization is given in one dose as a shot and can be given in a doctor’s office or pharmacy. There are two vaccines licensed and recommended to prevent shingles in the US: Zoster vaccine live (ZVL, Zostavax) and Recombinant zoster vaccine (RZV, Shingrix), with the latter being the preferred vaccine. Zostavax was licensed by the FDA in 2006 and reduces the risk of developing shingles by 51% and PHN by 67%. Shingrix, on the other hand, is an FDA-approved vaccine for the prevention of shingles in adults 50 years and older and is more than 90% effective at preventing shingles. Zoster immunization is recommended for people 60 years old and older, but someone with a minor acute illness, such as a cold, may still be vaccinated.