The Buffalo Bills have the following picks in the 2025 NFL Draft:

• Round 1: Pick 30 (CB Maxwell Hairston)
• Round 2: Pick 41 (DT T.J. Sanders, acquired from Chicago Bears), Pick 56 (from Vikings via Texans), Pick 62
• Round 3: Pick 72 (EDGE Landon Jackson, from Chicago Bears)
• Round 4: Pick 109 (from Bears), Pick 132
• Round 5: Pick 169 (compensatory), Pick 170 (from Cowboys via Commanders), Pick 173 (compensatory)
• Round 6: Pick 177 (from Giants), Pick 204 (from Detroit via Cleveland), Pick 206
• Round 7: Pick 240 (from Chicago Bears)

In total, the Bills have 10 selections spread across all rounds, with multiple picks in the middle rounds due to trades and compensatory picks

. They have focused on building depth on defense, selecting players such as cornerbacks, defensive tackles, and edge rushers