Derek Shepherd dies in Season 11 of Grey's Anatomy. Specifically, his death occurs in Season 11, Episode 21, titled "How to Save a Life." Derek is involved in a fatal car accident while driving to the airport for a final trip to Washington, and despite medical efforts, he suffers a brain injury that leads to his death after being declared brain dead. Meredith Grey, his wife, consents to remove him from life support during this episode