The internal temperature of meatloaf should be at least 160°F (71°C) when using ground beef, and 165°F (74°C) when using ground turkey. To ensure that the meatloaf is fully cooked and safe to eat, it is best to use a meat thermometer to check its temperature. It is recommended to check the temperature 10-15 minutes before the recipe says it will be done, as factors such as oven model and pan used can affect the cook time. It is important to avoid overcooking the meatloaf, as it can dry out. Meatloaf is typically cooked in a moderately-hot oven at 350°F (171°C), and there will be some carryover cooking, so it is best to pull it from heat at 155°F (68°C) .