According to multiple sources, Indiana has the most Powerball jackpot winners in the history of the game, with 39 wins since 1992. Missouri and Minnesota follow with 31 and 22 wins, respectively. Its important to note that not all states that play Powerball have had a jackpot winner, and some states have only had one or a few jackpot winners since the games inception. Additionally, five states (Alabama, Alaska, Hawaii, Nevada, and Utah) do not have state lotteries and do not participate in Powerball.